ProMatrX® ACF is an amniotic tissue allograft comprised of amnion and amniotic fluid containing
growth factors, cytokines and extracellular matrix proteins naturally found in amniotic tissue. Amnio Technology’s proprietary Advantek™ process preserves the original relevant characteristics of the tissue.
Key growth factors found in amniotic tissue allografts include:
- Fibroblast Growth Factor (FGF)
- Epidermal Growth Factor (EGF)
- Platelet Derived Growth Factor (PDGF) A & B
- Vascular Endothelial Growth Factor (VEGF)
- Transforming Growth Factor beta (TGFβ)
Extracellular matrix elements found in amniotic tissue allografts include:
- Collagen Types I, III, IV, V and VII
- Tissue Inhibitors of Metalloproteinases (TIMPs)
- Hyaluronic Acid
Item Number Size
ACF-050025 0.25 cc
ACF-050050 0.50 cc
ACF-050100 1.0 cc
ACF-050200 2.0 cc
Donor tissue is recovered using one of the safest recovery techniques and sterile equipment to minimize any bioburden contamination. Amniotic tissues are procured through a network of qualified and trained recovery partners, following stringent screening and recovery protocols in a highly controlled processing environment. All tissues are processed aseptically.
Communicable disease testing is performed by an FDA registered and Clinical Laboratory Improvement Amendments (CLIA Certified) laboratory. Donor blood sample is taken prior to or at the time of recovery and tested for HBsAg, HBcAb, HCVAb, HIV1/2 Ab, HCV NAT, HIV NAT, HBV NAT, RPR/STS, WNV, and HTLV I/II. Allografts are subjected to stringent USP testing prior to release.
1) Complements and the Wound Healing Cascade: An Updated Review. Hani Sinno and Satya Prakash. Plast Surg Int. 2013; 2013: 146764
2) The Grafting of Preserved Amniotic Membrane to Burned and Ulcerated Surfaces, Substituting Skin Grafts: A Preliminary Report. Maximilian Stern. JAMA. 1913; 60(13): 973-974
3) Amniotic Fluid: Not Just Fetal Urine Anymore. Mark A Underwood, William M Gilbert, Michael P Sherman. Journal of Perinatology. 2005; 25: 341-348
4) Growth factors and cytokines in wound healing. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Wound Repair Regen. 2008; 16(5): 585-601